Many CKD patients also experience complex and compounding burdens of disease, particularly once they progress to the stage of requiring hemodialysis. This notably includes anemia (aCKD), which is associated with a reduced quality of life and increased morbidity and mortality. Encouraging clinical trial data have recently emerged for hypoxia-inducible, factor prolyl hydroxylase inhibitor (HIF-PHI) therapeutics for patients on dialysis for CKD. This novel, targeted therapy is now FDA-approved and appears promising; healthcare providers should receive a data update on it. In addition, we recognize that the progressive and incurable nature of CKD remains a challenging journey for patients, specifically those undergoing dialysis. Optimal care and support of these patients and their caregivers are characterized by guidelines-concordant management of the kidney disease and related comorbidities, as well as a thorough understanding of stubborn disparities in the healthcare system that result in unequal access to high-quality care and improved outcomes.
Nephrologists, other internists, primary care providers, NPs and PAs, pharmacists, and other healthcare providers who care for patients with chronic kidney disease that is dialysis-dependent
- Understand the pathophysiology of chronic kidney disease anemia, unmet patient needs, and the overall burden of disease for patients on hemodialysis
- Analyze clinical trial data and clinical applications for hypoxia-inducible, factor prolyl hydroxylase inhibitor (HIF-PHI) therapeutics for patients on hemodialysis for CKD
- Collaborate with the healthcare team to address care disparities in the management of patients with CKD-associated anemia undergoing dialysis
I. Introduction, Welcome, Objectives – Jay Wish, MD
II. Stage 5 CKD Pathophysiology, Burden of Disease, and Unmet Patient Needs, and the Progression to Dialysis Dependency – Sophia Ambruso, MD
III. Science, Clinical Trial Update, and Potential Clinical Applications for Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor (HIF-PHI) Therapeutics for Patients on Hemodialysis for CKD – Robert Provenzano, MD
IV. Strategies to Address Care Delivery Disparities in the Management of Patients with CKD-Associated Anemia Undergoing Dialysis – Christine Chmielewski, NP and Jay Wish, MD
V. Faculty Panel Discussion – Jay Wish, MD and Faculty
Jay B. Wish, MD (Course Chair)
Medical Director, Out-Patient Dialysis Unit
Indiana University Hospital
Chief Medical Officer for Dialysis, IU Health
Professor of Clinical Medicine
Indiana University School of Medicine
Disclosures of Relevant Financial Relationships
It is the policy of AcademicCME that all faculty, instructors, and planners disclose relevant financial relationships relating to the topics of this educational activity. Any relevant financial relationships are mitigated via a content review by planning committee members and faculty with no relevant financial relationships.
The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CE activity:
|Relationship Identified With:
|Jay B. Wish, MD (Course Chair)
|Consultant/Advisor: Akebia; AstraZeneca; Dexcel Pharma; Disc Medicine; GlaxoSmithKline; Otsuka Pharmaceuticals
Speaker’s Bureau: AstraZeneca; Akebia; GlaxoSmithKline
|Christine M. Chmielewski, MS, CRNP
|Consultant/Advisor: GlaxoSmithKline; Vifor
Speaker’s Bureau: AstraZeneca
|Robert Provenzano, MD
|Consultant/Advisor: GlaxoSmithKline; FibroGen, Inc.
Stocks: Organic Arthritis; Nephroceuticals; Vasc-Alert
|Sophia Ambruso, MD
|Consultant/Advisor: AstraZeneca; GlaxoSmithKline
Planners and Peer Reviewers
Timothy Hayes, MD, PhD; Kim Cheramie, MSN, RN-BC; Nicole McMenamin and Chelsey Simonds hereby state that they or their spouse/life partner do not have any relevant financial relationships to products or devices with any commercial interests related to the content of this activity of any amount during the past 12 months.
In support of improving patient care, AcademicCME is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Credit Designation Statements
AcademicCME designates this enduring material for a maximum of 1.0 AMA PRA Category 1 CreditTM.
AcademicCME designates this enduring material for a maximum of 1.0 CNE Contact Hour, including 1.0 Pharmacotherapeutic Contact Hour (Provider #P0491).
Participants should claim only the credit commensurate with the extent of their participation in the activity.
This activity has been supported by an independent educational grant from GlaxoSmithKline.
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