Program Overview
This CME/CE activity is derived from content presented at the 6th Annual Advanced Curriculum for Multiple Sclerosis 2021 Virtual CME/CE Course. The expert faculty, led by Dr. Fred D. Lublin, will first outline the science, mode of action, and unmet needs for S1P modulator therapies for patients with relapsing multiple sclerosis, including immune factors and strategies for initiating treatment among other topics. Following, the expert faculty will analyze clinical trials data and current recommendations regarding cardiac monitoring for S1P modulator therapies to treat patients with multiple sclerosis (MS). Best practices for creating personalized treatment plans encompassing the healthcare team will also be reviewed. The faculty will conclude with an expert panel discussion, highlighting the role of S1P therapeutics in improving outcomes in multiple sclerosis patients.
Target Audience
Neurologists, MS specialists, nurse practitioners, physicians’ assistants, nurses, and pharmacists who comprise the comprehensive MS care team, as well as other healthcare professionals involved in the management of patients with multiple sclerosis
Learning Objectives
- Understand the science, mode of action, and unmet needs for S1P modulator therapies for patients with relapsing MS
- Analyze long-term clinical trial data concerning the safety, efficacy, and comparative effectiveness of cardiac monitoring for S1P modulator therapies to treat patients with MS
- Develop a more comprehensive treatment plan with the healthcare team that includes biomarkers for disease progression, brain volume loss, and preventing disease progression
Agenda
I. The Science, Mode of Action, and Unmet Needs for S1P Modulator Therapies for Patients with Relapsing MS – Clyde Markowitz, MD
II. A Clinical Trial Analysis on Long-Term Data for the Safety, Efficacy, and Comparative Effectiveness of Cardiac Monitoring for S1P Modulator Therapies to Treat Patients with MS – Ilana Katz-Sand, MD
III. Optimizing Patient-Focused Comprehensive Treatment Strategies for the MS Patient with the Healthcare Team – Mark Freedman, MD
IV. Expert Panel Discussion – Fred D. Lublin, MD and Faculty
Chair
F
red D. Lublin, MD
Saunders Family Professor of Neurology
Director, Corinne Goldsmith Dickinson Center for MS
Icahn School of Medicine at Mount Sinai
New York, New York
Faculty
Mark S. Freedman, MD
Professor of Medicine
University of Ottawa
Senior Scientist
Ottawa Hospital Research Institute
Ottawa, Ontario, Canada
Ilana Katz-Sand, MD
Assistant Professor, Department of Neurology
Icahn School of Medicine at Mount Sinai
Associate Medical Director
Corinne Goldsmith Dickinson Center for Multiple Sclerosis
Mount Sinai Hospital
New York, New York
Clyde Markowitz, MD
Director, MS Center
Associate Professor, Department of Neurology
Perelman School of Medicine
University of Pennsylvania
Philadelphia, Pennsylvania
Disclosures of Conflict of Interest
It is the policy of AcademicCME that all faculty, instructors, and planners disclose real or apparent conflicts of interest relating to the topics of this educational activity.
The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CE activity:
| Faculty | Relationship Identified With: |
| Fred D. Lublin, MD | Consultant/Advisor: Acorda Therapeutics; Actelion Pharmaceuticals Ltd; Apitope; Atara Biotherapeutics, Inc.; Avotres Inc.; Biogen; BrainStorm Cell Limited; Celgene Corporation; EMD Serono, Inc.; F. Hoffmann-La Roche Ltd; Genentech, Inc.; Greenwich Biosciences, a GW Pharmaceuticals PLC Company; Immunic Therapeutics; Innate Immunotherapeutics; Janssen Global Services, LLC; Jazz Pharmaceuticals, Inc.; Mapi-Pharma Ltd.; MedDay Pharmaceuticals; MedImmune Pharma; Mylan; Novartis AG; Orion Biotechnology; Polpharma; Population Council; Receptos; Sanofi Genzyme; Teva Pharmaceutical Industries Ltd.; TG Therapeutics, Inc.; Viela Bio
Grant/Research Support: Actelion Pharmaceuticals Ltd; Biogen; BrainStorm Cell Limited; Novartis AG; Sanofi Genzyme Speaker’s Bureau: Sanofi Genzyme |
| Mark S. Freedman, MD | Consultant/Advisor: Actelion Pharmaceuticals Ltd; Alexion Pharmaceuticals, Inc.; Atara Biotherapeutics, Inc.; Bayer AG; Biogen; Bristol-Myers Squibb; Celgene Corporation; Clene Nanomedicine, Inc.; EMD Serono, Inc. Canada; F. Hoffmann-La Roche Ltd; GRI Bio, Inc.; Magenta Therapeutics; Merck & Co., Inc; Novartis AG; Sanofi Genzyme Canada; Janssen Global Services, LLC; Teva Pharmaceutical Industries Ltd. Canada
Grant/Research Support: EMD Serono, Inc. Canada; F. Hoffmann-La Roche Ltd; Sanofi Genzyme Canada Speaker’s Bureau: EMD Serono, Inc. Canada; Sanofi Genzyme Canada |
| Ilana Katz-Sand, MD | Nothing to disclose |
| Clyde Markowitz, MD | Consultant/Advisor: Actelion Pharmaceuticals Ltd; Biogen; Bayer AG; Celgene Corporation; EMD Serono, Inc.; F. Hoffmann-La Roche Ltd; Genentech, Inc.; Novartis AG; Sanofi Genzyme; Teva Pharmaceutical Industries Ltd. |
Planners and Peer Reviewers
Timothy Hayes, MD, PhD; Kim Cheramie, MSN, RN-BC; John Fanikos, RPh; Amy Perrin Ross, APN, MSN, CNRN, MSCN; Nicole McMenamin and Chelsey Benedek hereby state that they or their spouse/life partner do not have any financial relationships to products or devices with any commercial interests related to the content of this activity of any amount during the past 12 months.
Accreditation Statement
In support of improving patient care, AcademicCME is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Credit Designation Statements
AcademicCME designates this enduring material for a maximum of 1.0 AMA PRA Category 1 CreditTM.
AcademicCME designates this enduring material for a maximum of 1.0 CNE Contact Hour.
AcademicCME designates this continuing education activity for 1.0 CPE Contact Hour (0.10 CEU) of continuing pharmacy education credit (JA4008190-0000-21-006-H04-P).
Clinicians should claim only the credit commensurate with the extent of their participation in the activity.
Financial Support
This activity has been supported by an independent educational grant from Bristol Myers Squibb.
Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. AcademicCME and Bristol Myers Squibb do not recommend the use of any agent outside of the labeled indications.
Disclaimer
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
Method of Participation
In order to claim credit, participants must complete the following:
- Read the learning objectives, accreditation information and faculty disclosures at the beginning of this activity.
- Complete the Pre-Activity Questions
- Read or Review the activity content.
- Complete the Post-Activity Test Questions and Evaluation.
- Learners who receive a grade of 70% or better on the Post-Activity Test Questions and complete the Evaluation will receive appropriate credit as indicated (CME, CNE, and/or CPE credit).
- CPE credit will be posted to the learner’s CPE Monitor profile within 60 days of completion.
- CME and CNE credit will be issued appropriate certificate of completion.
- Others may request a “certificate of completion”.
- Learners should claim only the credit commensurate with the extent of their participation in the activity.
CE Inquiries/Special Needs
For all CE inquiries or special needs, please contact [email protected].
