This CME/CE program is derived from content presented in conjunction with the Consortium of Multiple Sclerosis Centers 2025 Annual Meeting. The expert faculty, Dr. Claire Riley, will first highlight the evolving therapeutic landscape in multiple sclerosis, as well as the rationale for exploration of CAR T-cell therapy in autoimmune disease. Following, recent clinical trial data of CD19 CAR T-cell therapy in progressive multiple sclerosis (MS) will be analyzed, including a discussion of clinical implications for the practicing neurologist. At the conclusion of this program, clinicians will be better equipped to utilize current CAR-T cell science when making treatment decisions for patients with multiple sclerosis.
MS specialists, neurologists, and other healthcare professionals involved in the management of patients with multiple sclerosis
Review the mechanism of action and potential role of CAR T-cell therapy in managing neuroinflammation in patients with MS.
Review clinical trial data for CAR T-cell therapeutics in development for patients with MS who might benefit from this therapy.
Review biomarkers and the applications of CAR T-cell therapy in oncology and the transition from oncology to neurology.
Mechanism of Action and Potential Role of CAR T-cell Therapy in Managing Neuroinflammation in Patients with MS
Clinical Trial Data for CAR T-cell Therapeutics
Applications of CAR T-cell Therapy in Oncology and the Transition from Oncology to Neurology
It is the policy of AcademicCME that all faculty, instructors, and planners disclose relevant financial relationships with ineligible companies. Planners have no relevant financial relationships with ineligible companies to disclose related to this activity. Faculty
have disclosed the following relevant financial relationships. All relevant financial relationships have been mitigated.
| Faculty | Relationship Identified With: |
| Claire S. Riley, MD | Consultant/Advisor: Alumis Inc.; Amgen Inc.; Bristol Myers Squibb; EMD Serono Inc.; F. Hoffmann-La Roche Ltd; Genentech, Inc.; Immunic Therapeutics; Novartis Pharmaceuticals Corporation; TG Therapeutics, Inc. Grant/Research Support: EMD Serono Inc.; Novartis Pharmaceuticals Corporation |
Timothy Hayes, MD, PhD; Kim Cheramie, MSN, RN-BC; Nicole McMenamin and Chelsey Simonds hereby state that they do not have any relevant financial relationships to products or devices with any commercial interests related to the content of this activity.
In support of improving patient care, AcademicCME is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
AcademicCME designates this enduring material for a maximum of 0.75 AMA PRA Category 1 CreditsTM.
AcademicCME designates this enduring material for a maximum of 0.75 CNE Contact Hours, including 0.75 Pharmacotherapeutic Contact Hours (Provider #P0491).
Participants should claim only the credit commensurate with the extent of their participation in the activity.
This activity has been supported by an independent educational grant from Bristol Myers Squibb.
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. AcademicCME and Bristol Myers Squibb do not recommend the use of any agent outside of the labeled indications.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
In order to claim credit, participants must complete the following:
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