Anemia is a common complication in CKD (aCKD) and is associated with a reduced quality of life and increased morbidity and mortality. The mechanisms involved in aCKD are diverse and complex. They include a decrease in endogenous erythropoietin production, absolute and/or functional iron deficiency, and inflammation with increased hepcidin levels, among others. Patients are most commonly managed with oral or intravenous iron supplements and with erythropoiesis stimulating agents (ESA). However, these treatments have associated risks, and sometimes are insufficiently effective. Recently, there have been remarkable advances in the treatment of aCKD with hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs). These agents induce an increase in the production of endogenous EPO, improve iron availability, and reduce hepcidin levels. Our expert faculty will review the current knowledge of the pathophysiology of aCKD, current and emerging therapies, trends in patient management, and unmet treatment goals.
Nephrologists, Hematologists, Primary Care, Internal Medicine, Hospitalists, Cardiologists, Endocrinologists, Family Medicine, APPs, and other healthcare providers who care for patients with chronic kidney disease.
Review the pathophysiology of anemia of CKD and the importance of screening, early diagnosis, and early treatment
Analyze current clinical trial data and treatment options for managing patients with anemia of CKD
Discuss the burden of disease and current racial, gender, and socioeconomic disparities in patients with anemia of CKD
Welcome and Introductions
Clinical Update for Anemia of CKD: Pathophysiology, Screening, Early Diagnosis, and Early Treatment of Anemia of CKD
Clinical Trial Analysis: Current and Emerging Therapies for Anemia of CKD and When to Apply
Essential Clinical Strategies to Improve All Patients Outcomes: Modifying Treatments and Recognizing the Impact of Racial, Gender, and Socioeconomic Disparities in Patients with Anemia of CKD
Faculty Panel Discussion
It is the policy of AcademicCME that all faculty, instructors, and planners disclose relevant financial relationships relating to the topics of this educational activity. Any relevant financial relationships are mitigated via a content review by planning committee members and faculty with no relevant financial relationships.
The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CE activity:
| Faculty | Relationship Identified With: |
| Jay B. Wish, MD (Course Chair) | Consultant/Advisor: Akebia; AstraZeneca; CSL Behring; Dexcel Pharma; Disc Medicine; FibroGen, Inc.; GlaxoSmithKline; Otsuka Pharmaceutical; Rockwell Medical
Speaker’s Bureau: Akebia; AstraZeneca |
| Daniel W. Coyne, MD | Consultant/Advisor: Akebia; AstraZeneca; Boehringer Ingelheim International GmbH; Daiichi Sankyo Company, Limited; FMC-Renal Therapies Group; Fresenius Kabi; Lilly; Otsuka Pharmaceutical; Travere Therapeutics, Inc.; Unicycive Therapeutics
Grant/Research Support: AstraZeneca Speaker’s Bureau: AstraZeneca Canada; Fresenius Kabi |
| Ellie Kelepouris, MD | Consultant/Advisor: Akebia; AstraZeneca; Bayer Pharmaceuticals; Boehringer Ingelheim International GmbH; GlaxoSmithKline; Relypsa; Up to Date
Speaker’s Bureau: AstraZeneca |
| Hector M. Madariaga, MD | Consultant/Advisor: Vifor Medical |
Timothy Hayes, MD, PhD; Kim Cheramie, MSN, RN-BC; Nicole McMenamin and Chelsey Simonds hereby state that they or their spouse/life partner do not have any relevant financial relationships to products or devices with any commercial interests related to the content of this activity of any amount during the past 12 months.
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