Dr. Shoamanesh is an Associate Professor of Medicine (Neurology) at McMaster University, where he holds the Marta and Owen Boris Chair in Stroke Research and Care, and the founding Director of the Hemorrhagic Stroke Research Program and a Scientist at the affiliated Population Health Research Institute.

His clinical trials program is working on establishing new treatments and standards of care that prevent stroke and reduce stroke-related disability. He leads several national and international multicentre randomized trials as PI/Co-PI, including the global main phase ENRICH-AF trial (NCT03950076) investigating optimal stroke prevention in intracranial hemorrhage survivors with atrial fibrillation and the phase 3 OCEANIC-STROKE trial (NCT05686070) investigating the novel direct factor XIa inhibitor (asundexian) for stroke prevention in patients with acute non-cardioembolic ischemic stroke/TIA. He is the founding chair of the Canadian HEmorrhagic Stroke trIals InitiatiVE (CoHESIVE; www2.phri.ca/cohesive/) and is lead author of the inaugural Canadian Stroke Best Practice Recommendations on the Management of Spontaneous Intracerebral Hemorrhage. He additionally serves on the leadership teams of several public and industry funded randomized trials in the fields of cerebrovascular and cardiovascular disease. Dr. Shoamanesh has published a large number of manuscripts in leading scientific journals and serves on the editorial boards of Stroke, International Journal of Stroke and Canadian Journal of Neurological Sciences. His contributions to stroke research and leadership in the field have been recognized by several prominent international organizations, such as the European Stroke Conference (2015 Young Investigator Award), American Heart/Stroke Association (2015 Globus, 2019 Siekert and 2019 Dudley White Awards), Heart and Stroke Foundation of Canada (2019 Barnett Scholarship), American Academy of Neurology (2020 Pessin Prize), World Stroke Organization (2020 Future Stroke Leaders Program and 2023 World Stroke Congress Scientific Committee Co-Chair), and World Intracranial Hemorrhage Conference (2023 Co-Chair).