Accurate Diagnosis and Emerging Neutrophil Serine Protease Therapeutics for Patients with Non-Cystic Fibrosis Bronchiectasis

Program Dates: September 30th, 2022 - September 29th, 2023
Credits: 0.75 AMA PRA Category 1 Credits™

Accurate Diagnosis and Emerging Neutrophil Serine Protease Therapeutics for Patients with Non-Cystic Fibrosis Bronchiectasis

Program Overview

This CME program is derived from content presented at the 2022 Eastern Pulmonary Conference. The expert faculty, Dr. Gregory Tino, will first outline the pathophysiology, prevalence and radiological distribution of non-cystic fibrosis bronchiectasis (NCFBE). Current treatment guidelines and recommendations for patients with NCFBE will be reviewed and an overview of phenotyping provided. Dr. Tino will conclude with an analysis of current trial data, including a discussion of practical implications for clinicians who treat and manage patients with non-cystic fibrosis bronchiectasis.

Target Audience

Pulmonologists, primary care physicians, radiologists, advanced practitioners, and other healthcare professionals who care for patients with NCFBE


I. Scientific Review of NCFBE, Including Disease Burden and Diagnostic Techniques

II. Review of NCFBE Pathophysiology, Natural History and Clinical Progression

III. Clinical Trial Review of Dipeptidyl Peptidase 1 (DPP1) Therapeutics for the Treatment of NCFBE

Learning Objectives

  1. Understand the science of NCFBE, including disease burden, unmet needs, patient risk factors and comorbidities, and early and accurate diagnostic techniques that can reduce treatment delays
  2. Review NCFBE pathophysiology, natural history and clinical progression
  3. Analyze the role of neutrophilic inflammation and neutrophil serine proteases in NCFBE and review clinical trial data on dipeptidyl peptidase 1 (DPP1) therapeutics.


Sidney S. Braman, MD
Professor of Medicine, Emeritus
Icahn School of Medicine at Mount Sinai
New York, NY



Gregory Tino, MD
Associate Professor of Medicine
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania



Disclosures of Relevant Financial Relationships

It is the policy of AcademicCME that all faculty, instructors, and planners disclose relevant financial relationships relating to the topics of this educational activity. Any relevant financial relationships are mitigated via a content review by planning committee members and faculty with no relevant financial relationships.

The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CE activity:

Faculty Relationship Identified With:
Sidney S. Braman, MD Nothing to disclose
Gregory Tino, MD Consultant/Advisor: AstraZeneca; Insmed

Planners and Peer Reviewers

Timothy Hayes, MD, PhD; Kim Cheramie, MSN, RN-BC; Nicole McMenamin and Chelsey Benedek hereby state that they or their spouse/life partner do not have any relevant financial relationships to products or devices with any commercial interests related to the content of this activity of any amount during the past 12 months.

Accreditation Statement

In support of improving patient care, AcademicCME is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.



Credit Designation Statements

AcademicCME designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credits TM.

Clinicians should only claim credit commensurate with the extent of their participation.

Financial Support

This activity has been supported by an independent educational grant from Insmed.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. AcademicCME and Insmed do not recommend the use of any agent outside of the labeled indications.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Method of Participation

In order to claim credit, participants must complete the following:

  1. Read the learning objectives, accreditation information and faculty disclosures at the beginning of this activity.
  2. Complete the Pre-Activity Questions
  3. Read or Review the activity content.
  4. Complete the Post-Activity Test Questions and Evaluation.
  5. Learners who receive a grade of 60% or better on the Post-Activity Test Questions and complete the Evaluation will receive appropriate credit as indicated (CME, CNE, and/or CPE credit).
  • CPE credit will be posted to the learner’s CPE Monitor profile within 60 days of completion.
  • CME and CNE credit will be issued appropriate certificate of completion.
  • Others may request a “certificate of completion”.
  1. Learners should claim only the credit commensurate with the extent of their participation in the activity.

CE Inquiries/Special Needs

For all CE inquiries or special needs, please contact [email protected].


Provided by: AcademicCME-web