Amyloid plaques on axons of neurons affected by Alzheimer's disease

Early Diagnosis and Disease Monitoring: Pathology and Biomarkers

Program Overview

In this module of a Four-Part Expert Interview Series, Dr. James E. Galvin, along with Dr. Richard S. Isaacson, course chair, will relay optimal strategies for early diagnosis of Alzheimer’s disease (AD). Signs and symptoms for the mild, moderate and severe forms of AD will be analyzed, as well as modifiable and non-modifiable risk factors. The faculty will also review biomarkers of disease, along with their clinical relevance. Upon completing this educational activity, participants will feel more confident in their understanding of early diagnosis and disease monitoring in the AD patient population.

Target Audience

Neurologists, internists, nurse practitioners, nurses and other healthcare professionals involved in the management of patients with Alzheimer’s disease.

Learning Objectives

I. Review the pathology of Alzheimer’s disease, including disease monitoring and specific biomarkers for early diagnosis

II. Identify the assessment and testing strategies for early diagnosis, monitoring, and personalized treatment of AD


Isaacson Head ShotRichard S. Isaacson, MD
Associate Professor of Neurology
Director, Alzheimer’s Prevention Clinic
Weill Cornell Medicine
New York Presbyterian Hospital
New York, New York



Screen Shot 2017-12-06 at 10.59.46 AMJames E. Galvin, MD, MPH
Professor and Associate Dean for Clinical Research
Director, Comprehensive Center for Brain Health
Charles E. Schmidt College of Medicine
Florida Atlantic University
Boca Raton, Florida


Disclosures of Conflict of Interest

It is the policy of AcademicCME that all faculty, instructors, and planners disclose real or apparent conflicts of interest relating to the topics of this educational activity.

The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity.

FacultyRelationship Identified With:
Richard S. Isaacson, MDConsultant/Advisor: Eli Lilly and Company; Neurotrack; 23 and Me
James E. Galvin, MD, MPHNothing to disclose.

Planners, Managers, Reviewers

Timothy Hayes, MD, PhD; Emma Boring; Nicole Brestowski, Chelsey Benedek and Kim Cheramie, MSN, RN-BC hereby state that neither they nor their spouse/life partner have any financial relationships to products or devices with any commercials interest related to the content of this activity of any amount during the past 12 months.

Accreditation Statement

AcademicCME is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

AcademicCME is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation

Credit Designation Statement

AcademicCME designates this enduring material for a maximum of .50 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

AcademicCME designates this enduring material for a maximum of .50 CNE contact hours.

Financial Support

This activity has been supported by an independent educational grant from Biogen.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. AcademicCME and Biogen do not recommend the use of any agent outside of the labeled indications.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Method of Participation

In order to claim credit, participants must complete the following:

  1. Read the learning objectives, accreditation information and faculty disclosures at the beginning of this activity.
  2. Complete the Pre-Activity Questions.
  3. Read or Review the activity content.
  4. Complete the Post-Activity Test Questions and Evaluation.
  5. Healthcare providers who receive a grade of 66% or better on the Post-Activity Test Questions and who complete the Evaluation will receive a CME/CNE Certificate.
  6. All other participants who receive a grade of 66% or better on the Post-Activity Test Questions and who complete the Evaluation will receive a Certificate of Participation.
  7. Healthcare providers should claim only the credit commensurate with the extent of their participation in the activity.
  8. 60 minutes of participation = 1 CNE contact hour

CE Inquiries/Special Needs

For all CME/CNE inquiries or special needs, please contact [email protected].